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Page 1
Development and Utility of a PAK1-Selective Degrader.
J Med Chem. 2022 Dec 8;65(23):15627-15641. doi: 10.1021/acs.jmedchem.2c00756. Epub 2022 Nov 23.
J Med Chem. 2022.
PMID: 36416208
Free PMC article.
Regulation of MST complexes and activity via SARAH domain modifications.
Karchugina S, Benton D, Chernoff J.
Karchugina S, et al.
Biochem Soc Trans. 2021 Apr 30;49(2):675-683. doi: 10.1042/BST20200559.
Biochem Soc Trans. 2021.
PMID: 33860801
Free PMC article.
Review.
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Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling.
Sementino E, Kadariya Y, Cheung M, Menges CW, Tan Y, Kukuyan AM, Shrestha U, Karchugina S, Cai KQ, Peri S, Duncan JS, Chernoff J, Testa JR.
Sementino E, et al. Among authors: karchugina s.
Mol Cancer Res. 2022 May 4;20(5):699-711. doi: 10.1158/1541-7786.MCR-21-0837.
Mol Cancer Res. 2022.
PMID: 35082167
Free PMC article.
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Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2).
Shen YC, Arellano-Garcia C, Menjivar RE, Jewett EM, Dohle W, Karchugina S, Chernoff J, Potter BVL, Barald KF.
Shen YC, et al. Among authors: karchugina s.
BMC Pharmacol Toxicol. 2019 Nov 15;20(1):67. doi: 10.1186/s40360-019-0369-8.
BMC Pharmacol Toxicol. 2019.
PMID: 31730023
Free PMC article.
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Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay.
Karchugina S, Chernoff J.
Karchugina S, et al.
J Vis Exp. 2018 Oct 20;(140):57755. doi: 10.3791/57755.
J Vis Exp. 2018.
PMID: 30394375
Free PMC article.
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PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2).
Hawley E, Gehlhausen J, Karchugina S, Chow HY, Araiza-Olivera D, Radu M, Smith A, Burks C, Jiang L, Li X, Bessler W, Masters A, Edwards D, Burgin C, Jones D, Yates C, Clapp DW, Chernoff J, Park SJ.
Hawley E, et al. Among authors: karchugina s.
Hum Mol Genet. 2021 Aug 12;30(17):1607-1617. doi: 10.1093/hmg/ddab106.
Hum Mol Genet. 2021.
PMID: 34075397
Free PMC article.
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A novel direct spray-from-tissue ionization method for mass spectrometric analysis of human brain tumors.
Kononikhin A, Zhvansky E, Shurkhay V, Popov I, Bormotov D, Kostyukevich Y, Karchugina S, Indeykina M, Bugrova A, Starodubtseva N, Potapov A, Nikolaev E.
Kononikhin A, et al. Among authors: karchugina s.
Anal Bioanal Chem. 2015 Oct;407(25):7797-805. doi: 10.1007/s00216-015-8947-0. Epub 2015 Aug 16.
Anal Bioanal Chem. 2015.
PMID: 26277186
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